We stay in Skamania lodge a couple times a year. I've seen Fabio a bunch in their breakfast thing. One time the waitress came over to us crying because he knew her pretty well and her husband had just died and he said he was going to pay for the casket, or some really substantial part of it.I usually stay across the river from Hood River on the Washington side at least once each year. Girlfriend's family has a house there. Not a big brewery guy but will have to check out.I stay in good river every year. Their beer scene is better than almost everywhere else.Alll depends on style of beer at this point. I could pick it a dozen "best brewery" based on what I'm drinking. Pfriem is on the overall top tier, though. Many good things there.
If we have our kids with us we stay on the Hood River side, because despite their effort Skamania still kind of sucks for kid activities.
Thunder Bay Brewing in Cascade Locks is the place I most recommend because it's such a nice facility, and in the summer there used to be all sorts of other fans to talk to, whether quooks or Cal/Stanford bros trying to windsurf/hike or whatever.
In general I just have had a way better time in that area than Bend, but I don't ski or care for a lot of the stuff in that area which is a big reason.