I will make a Moscow Mule that will have you faced on the floor before you realize it. Have done this to many people before who "didn't really like moscow mules". It was one of my family's favorite drinks going back to prohibition days and I was forced to make them from about the age of 13 for said family. As DDY said ABC and then the other key is your ginger beer which varies wildly in taste and quality but it MUST be relatively fresh. Muddling or slapping fresh mint can also drastically change the drink but isn't "required". The copper mug does make a difference but really any metal cup will do.
My go to is still a whiskey sour but the Moscow Mule is something that more of my friends(and more specifically the wife's friends) will drink so I end up making them regularly at the house.
At least you admit to putting roofies in your drinks.
You don't need pharmaceuticals to knock someone out if you're a good bartender. Booze is a more than adequate neurotoxin.