Would be the biggest win probably since 2009 USC. You have to remember the Huskies were coming off 0-12 that year and USC was undefeated, fresh off winning at Ohio State (coincidence, I think not), and coming off 2008 when they were legitimately really good. 2016 Stanford could have been a bigger win at the time - they came in #7, undefeated with 3 good wins, and defending Pac-12 champs.
This game should remind of the 2012 Oregon State game coming in - a Top 10 conference team that's probably not as good as their ranking but who has done well with their schedule coming in ripe for a beating in Seattle. Unfortunately, I think this Husky team is too inept to do that, it's a bad matchup, and Oregon won't be sleeping on this since it's a "rivalry."